Little Sisters (originally named as Gatherers by the game developers) are young girls who have been genetically altered and mentally conditioned to reclaim ADAM from corpses around Rapture. Little Sisters are almost always accompanied by a Big Daddy. They generally are immune to damage, outside of being "harvested", and have no offensive abilities. Attacking them, however, will incur the wrath of their Big Daddy protectors. Papercraft from Raven.
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